Barts Pancreas Tissue Bank (BPTB)

Project summary

The Barts Pancreas Tissue Bank (BPTB) is a unique and vital resource for researchers to provide a multitude of specimen types from pancreas disease and cancer patients as well as healthy controls. The samples are mainly collected from the Royal London Hospital and curated at Barts Cancer Institute.

The project primarily recruits donors identified within Barts Health NHS Trust, and requires primary and secondary care data of specific data categories for these donors. All registered donors provide signed informed consent to be a part of the tissue bank, and their personal medical history is collected along with the donated tissue samples.

The extensive primary and secondary care data provided by the DDS BPTB query helps to build a world-class repository of bio-specimens with most comprehensive clinical annotation. It also allows researchers to design innovative studies and build new insights on pancreatic cancer utilising the verified so-far-complete healthcare trajectory data associated with the BPTB samples.

For more information see https://www.bartspancreastissuebank.org.uk/

Project population

All donors registered at Barts Pancreas Tissue Bank.

Project cohort

All donors.

Project criteria

Full GP dataset to include:

• General

• Date of birth
• NHS number
• Gender
• Ethnicity
• Death
• Height
• Weight
• BMI/obesity

• Diagnosis:

• Malignancies
• Carcinoma in situ
• Benign neoplasm
• Neoplasm of uncertain behaviour
• Hernia
• Other disease and disorders

• Symptoms:

• Weight
• Nausea
• Appetite
• Vomit
• Diarrrhoea
• Constipation
• Digestive system symptoms
• Gastroinstinal symptoms
• Pain
• Jaundice
• Urine
• Skin
• Blood clot
• Swelling, lump or mass
• Pruritus

• Medical history:

• Diabetes
• Asthma
• Other
• Cholesterol
• Hypertension
• Heart
• Stroke
• Kidney
• Lung
• Liver
• Cancer

• Lifestyle:

• Smoking
• Alcohol
• Drug

• Physical exam:

• Jaundice
• Abdominal mass
• Lymph node

• Family history:

• Diabetes
• GI disease
• Cancer

• Blood test:

• Hb
• WCC
• Plt
• INR
• Alb
• Na
• K
• Urea
• Creat
• eGFR
• Bil
• ALT
• AST
• ALP
• GGT
• CRP
• CEA
• CA
• Other tumor marker
• T Prot

• Urine test:

• SG
• Glucose
• Protein
• Ketone
• Blood
• pH
• Nitrite
• Leykocyte
• Electrolyte
• Bile product
• General

• Surgical procedures:

• Abdominal organs
• Digestive tract

• Medication-SNOMED:

• ACAMPROSATE
• ACE Inhibitor (benazepril, captopril, ramipril)
• acetylcholine receptor antagonist (Pirenzepine, Tolterodine)
• Acitretin
• Adrenergic alpha-agonists (BRIMONIDINE, DOXAZOSIN, Indoramin)
• Analgesics (Co Codamol, BUPRENORPHINE, Butrans Patches, )
• Analgesics (Co Codamol, BUPRENORPHINE, Butrans Patches, fentanyl, Co-Dydramol, codeine, Methadone, Tramadol)
• Analgesics (Co Codamol, BUPRENORPHINE, Butrans Patches)
• Analgesics (Co Codamol, BUPRENORPHINE, Butrans Patches)
• Analgesics (Co Codamol, BUPRENORPHINE, Butrans Patches)
• Anesthetic (Propofol)
• Anti Histamine (chloropyrilene, Cyclizine, Hydroxyzine, Loratadine, Fexofenadine, RANITIDINE)
• Antiarrhythmic agent (Digoxin, Flecainide, Phenytoin)
• Antiarrhythmic agent (Digoxin, Flecainide, Phenytoin)
• Antibacterial (Cefaclor,CEPHALEXIN,erythromycin, Fusidic Acid, OXYTETRACYCLINE, TRIMETHOPRIM, VANCOMYCIN)
• Antibiotic & PENICILLIN (amoxicillin, ampicillin, Phenoxymethylpenicillin)
• Anticoagulant (rivaroxaban, Warfarin, Sinthrome)
• Anticoagulant (rivaroxaban, Warfarin, Sinthrome)
• Anticonvulsant(CARBAMAZEPINE, GABAPENTIN, LAMOTRIGINE, LEVETIRACETAM, Sodium valproate)
• Anticonvulsant(CARBAMAZEPINE, GABAPENTIN, LAMOTRIGINE, LEVETIRACETAM, Topiramate)
• Antidepressant (Amitriptyline, Dosulepin hydrochloride, Dothiepin, Doxepin, LOFEPRAMINE, Nortriptyline)
• Antidepressant (Mirtazapine)
• Antifungal (Terbinafine)
• Antihypertensive (Amlodipine, Telmisartan, IRBESARTAN)
• Antileukotriene (Montelukast, Zafirlukast)
• Antilipemic agent (Bezafibrate, Ciprofibrate, Colestyramine), zetimibe, Fenofibrate)
• Antilipemic agent (Bezafibrate, Ciprofibrate, Colestyramine), zetimibe, Fenofibrate)
• Antimalarial (Hydroxychlorine/Hydroxychloroquine, quinine)
• Antimetabiolite (MERCAPTOPURINE)
• Antineoplastic agent (HYDROXYUREA)
• Antiplatelet agent (clopidogrel, Aspirin, DIPYRIDAMOLE, PRASUGREL, Ticagrelor)
• Antispasmodic (Alverine, Mebeverine,Oxybutynin, Solifenacin)
• Antispasmodic (Alverine, Mebeverine,Oxybutynin, Solifenacin)
• Antithyroid agent (thiourea, Carbimazole, thiamazole)
• Antiviral (ACICLOVIR)
• benzofuran (Amiodarone, CITALOPRAM, dronedarone )
• Beta Blocker (Timolol, Propranolol, ATENOLOL, Nebivolol, Salbutamol, Salmeterol, Terbutaline)
• Birth Control/CONTRACEPTIVE
• Brinzolamide
• Bronchodilator (Ipratropium Bromide, TIOTROPIUM, Braltus Powder, Spiriva)
• Calcium (ADCAL, Acetate, phosphate, sulfate, antacid)
• Calcium channel blocker (Amlodipine, Diltiazem, VERAPAMIL, Nifedipine, ADALAT, ADIZEM)
• Cancer drugs/pyrimidine analog (Capecitabine, fluorouracil, gemcitabine, uracil)
• CARBOCISTEINE
• carbohydrate derivative (Glucosamine, Glycerol)
• Carbomer
• CINACALCET
• Co-trimoxazole (Septrin)
• Darbepoetin alfa (Aranesp)
• Digestant (pancreatin, pancrelipase/Creon)
• Diuretic
• dopamine receptor agonist (Cabergoline, Co-Careldopa, LEVODOPA,PRAMIPEXOLE,ROPINIROLE)
• dopamine receptor antagonist (Domperidone, amoxapine, chlorpromazine, METOCLOPRAMIDE)
• ELECTROLYTES
• Enzyme inhibitor (allopurinol, alogliptin, anastrozole, Celecoxib,Cilostazol, DUTASTERIDE, Exemestane, FINASTERIDE, LETROZOLE, LINAGLIPTIN, Rabeprazole)
• Estrogen (Estradiol, Diethylstilbestrol, Premarin)
• Estrogen receptor antagonist (tamoxifen)
• Exenatide
• Fesoterodine Fumarate (Toviaz)
• GABA agonist (baclofen, zolpidem)
• Gastrointestinal agent (Mesalazine/Mezavant)
• Gastrointestinal agent (Antacids)
• Gastrointestinal agent (Sulfasalazine, SALAZOPYRIN)
• Gastrointestinal agent
• Glucocorticoid (Beclomethasone, Budesonide, clenil, CLOBETASOL, Dexamethasone, FLUDROCORTISONE, Fluticasone,prednisolone, Triamcinolone)
• Gonad regulting hormone (goserelin/Zoladex)
• Haloperidol
• HRT
• Hypoglycemic agent (METFORMIN)
• Hypromellose
• imidazoline receptor agonist (MOXONIDINE)
• Immunomodulator (Azathioprine, Leflunomide, METHOTREXATE, Mycophenolate)
• Immunomodulator (Histamine)
• Insulin (Humalog, humulin, isophane. Lantus, Levemir)
• Iron (Ferrous Fumarate, Ferrous Gluconate, Ferrous Sulphate)
• Iron sucrose (Venofer)
• LAXATIVES (bisacodyl, carmellose, Lactulose, Docusate Sodium, Macrogol, PRUCALOPRIDE)
• LAXATIVES (bisacodyl, carmellose, Lactulose, Docusate Sodium, Macrogol, PRUCALOPRIDE)
• Lipase inhibitor (Orlistat)
• LOPERAMIDE
• Low molecular weight heparin (enoxaparin, Dalteparin, tinzaparin )
• Melatonin
• Monoclonal antibody (trastuzumab/Herceptin)
• Multivitamins
• Muscarinic receptor antagonist (Pirenzepine, Tolterodine, TIOTROPIUM)
• N-Acetylcysteine
• Nicotine Patch/Gum
• Non-Steroidal Anti-Inflammatory Drugs/NSAIDS (DICLOFENAC , Ibuprofen, ANADIN, Naproxen, Nefopam, Felbinac Gel)
• Omega-3 fatty acid (Omacor)
• Oxaliplatin
• Piperazine (Clozapine, CYCLIZINE)
• PPAR agonists (Pioglitazone, Rosiglitazone)
• PPV (PNEUMOCOCCAL POLYSACCHARIDE VACCINE)
• Prostaglandin (Bimatoprost, Latanoprost, misoprostol)
• Psychotropic agent (Duloxetine, Paroxetine, Venlafaxine)
• Psychotropic agent (Flupentixol,Sulpiride,Olanzapine, Quetiapine)
• Risedronate
• Sedative (benzodiazepine) (Clonazepam, diazepam, lorazepam, Midazolam)
• Sedative (Zopiclone)
• Senna/Senokot
• serotonin re-uptake inhibitor (Fluoxetine, SERTRALINE)
• serotonin receptor agonist (Rizatriptan, Sumatriptan, Zolmitriptan)
• Setrons/Antiemetics (ONDANSETRON)
• SGLT2 inhibitor (CANAGLIFLOZIN, Empagliflozin)
• Silver Nitrate Sticks
• Somatostatin analog (Lanreotide/Somatuline, Octreotide)
• Statin (ATORVASTATIN, CERIVASTATIN, ROSUVASTATIN, Simvastatin)
• Steroid
• Sulfonylurea (Gliclazide, Glimepiride)
• Synthetic hormone (DESMOPRESSIN, cyclofenil)
• Thyroid hormone (Thyroxine,Levothyroxine Sodium)
• Urea Cream
• Vasoconstrictor
• Vasoconstrictor (Sumatriptan)
• Vasodilators (Betahistine, Nicorandil, Isosorbide, Angitil)
• Vitamin B (Folic Acid, Thiamine, Renavit)
• Vitamin B12 (Cyanocobalamin)
• Vitamin D (Alfacalcidol, ADCAL D3)
• Vitamin K
• Zinc

Data state

Patient identifiable.

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